Alpha-1 antitrypsin deficiency
Meaning of alpha-1 antitrypsin deficiency: For the purposes of this Statement of Principles, alpha-1 antitrypsin deficiency means a genetic disorder of plasma protein metabolism which involves reduced serum levels of alpha-1 antitrypsin.
Reasonable Hypothesis (RH) — Statement of Principles No. 33 of 2023
At least one of the following factors must as a minimum exist before it can be said that a reasonable hypothesis has been raised connecting alpha-1 antitrypsin deficiency or death from alpha-1 antitrypsin deficiency with the circumstances of a person's relevant service:
- (1)having smoked tobacco products in an amount of at least 5 pack-years before the clinical worsening of alpha-1 antitrypsin deficiency;
Note: one pack-year is defined in the Schedule 1 - Dictionary.
- (2)inability to obtain appropriate clinical management for alpha-1 antitrypsin deficiency;
Aggravation-only factors: the factors in subsections 9(1) and 9(2) apply only to material contribution to, or aggravation of, the condition where it was suffered or contracted before or during (but did not arise out of) the person’s relevant service.
Balance of Probabilities (BoP) — Statement of Principles No. 34 of 2023
2 factors
At least one of the following factors must exist before it can be said that, on the balance of probabilities, alpha-1 antitrypsin deficiency or death from alpha-1 antitrypsin deficiency is connected with the circumstances of a person's relevant service:
- (1)having smoked tobacco products in an amount of at least 5 pack-years before the clinical worsening of alpha-1 antitrypsin deficiency;
Note: one pack-year is defined in the Schedule 1 - Dictionary.
- (2)inability to obtain appropriate clinical management for alpha-1 antitrypsin deficiency;
Aggravation-only factors: the factors in subsections 9(1) and 9(2) apply only to material contribution to, or aggravation of, the condition where it was suffered or contracted before or during (but did not arise out of) the person’s relevant service.








