Chronic myeloid leukaemia
Meaning of chronic myeloid leukaemia: For the purposes of this Statement of Principles, chronic myeloid leukaemia: (a) means a malignant neoplasm of the blood with a predominant overpopulation of the myeloid cells and the presence of a Philadelphia chromosome or a BCR-ABL1 gene or BCR-ABL1 gene product; and (b) excludes: (i) atypical chronic myeloid leukaemia; (ii) chronic eosinophilic leukaemia; (iii) chronic neutrophilic leukaemia; (iv) leukemoid reactions; and (v) myelomonocytic leukaemia.
Reasonable Hypothesis (RH) — Statement of Principles No. 57 of 2023
At least 1 of the following factors must as a minimum exist before it can be said that a reasonable hypothesis has been raised connecting chronic myeloid leukaemia or death from chronic myeloid leukaemia with the circumstances of a person's relevant service:
- (1)having received a cumulative equivalent dose of at least 0.01 sievert of ionising radiation to the bone marrow at least 1 year before the clinical onset of chronic myeloid leukaemia;
Note: cumulative equivalent dose is defined in the Schedule 1 - Dictionary.
- (2)undergoing ablative treatment with radioactive iodine for thyroid cancer before the clinical onset of chronic myeloid leukaemia, where the first exposure occurred at least 1 year before the clinical onset of chronic myeloid leukaemia;
- (3)being obese for at least 10 years within the 20 years before the clinical onset of chronic myeloid leukaemia;
Note: being obese is defined in the Schedule 1 - Dictionary.
- (4)being exposed to benzene as specified: (a) for a cumulative total of at least 2,500 hours within a continuous period of 5 years before the clinical onset of chronic myeloid leukaemia; and (b) where the first exposure in that period occurred at least 5 years before the clinical onset of chronic myeloid leukaemia; and (c) where the last exposure in that period occurred within the 30 years before the clinical onset of chronic myeloid leukaemia;
Note: being exposed to benzene as specified is defined in the Schedule 1 - Dictionary.
- (5)receiving greater than 10 ppm-years of cumulative exposure to benzene before the clinical onset of chronic myeloid leukaemia, and: (a) where the first exposure occurred at least 10 years before the clinical onset of chronic myeloid leukaemia; and (b) where the last exposure occurred within the 30 years before the clinical onset of chronic myeloid leukaemia;
Note: ppm-years is defined in the Schedule 1 - Dictionary.
- (6)having received a kidney transplant before the clinical onset of chronic myeloid leukaemia;
- (7)inability to obtain appropriate clinical management for chronic myeloid leukaemia;
Aggravation-only factors: the factors in subsection 9(7) apply only to material contribution to, or aggravation of, the condition where it was suffered or contracted before or during (but did not arise out of) the person’s relevant service.
Balance of Probabilities (BoP) — Statement of Principles No. 58 of 2023
3 factors
At least one of the following factors must exist before it can be said that, on the balance of probabilities, chronic myeloid leukaemia or death from chronic myeloid leukaemia is connected with the circumstances of a person's relevant service:
- (1)having received a cumulative equivalent dose of at least 0.05 sievert of ionising radiation to the bone marrow at least 2 years before the clinical onset of chronic myeloid leukaemia;
Note: cumulative equivalent dose is defined in the Schedule 1 - Dictionary.
- (2)undergoing ablative treatment with radioactive iodine for thyroid cancer before the clinical onset of chronic myeloid leukaemia, where the first exposure occurred at least 2 years before the clinical onset of chronic myeloid leukaemia;
- (3)inability to obtain appropriate clinical management for chronic myeloid leukaemia;
Aggravation-only factors: the factors in subsection 9(3) apply only to material contribution to, or aggravation of, the condition where it was suffered or contracted before or during (but did not arise out of) the person’s relevant service.
