Rapidly progressive crescentic glomerulonephritis
Meaning of rapidly progressive crescentic glomerulonephritis: For the purposes of this Statement of Principles, rapidly progressive crescentic glomerulonephritis means a form of glomerulonephritis where there are extensive cellular crescents on histopathology and a rapid decline in renal function over a period of weeks to months.
Reasonable Hypothesis (RH) — Statement of Principles No. 45 of 2019
At least one of the following factors must as a minimum exist before it can be said that a reasonable hypothesis has been raised connecting rapidly progressive crescentic glomerulonephritis or death from rapidly progressive crescentic glomerulonephritis with the circumstances of a person's relevant service:
- (1)having an infection from the specified list of infections within the two months before the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of infections is defined in the Schedule 1 - Dictionary.
- (2)having an autoimmune disorder from the specified list of autoimmune disorders at the time of the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of autoimmune disorders is defined in the Schedule 1 - Dictionary.
- (3)having infiltration of the kidneys due to a disorder from the specified list of infiltrative disorders at the time of the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of infiltrative disorders is defined in the Schedule 1 - Dictionary.
- (4)having a renal disorder from the specified list of renal disorders at the time of the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of renal disorders is defined in the Schedule 1 - Dictionary.
- (5)having a malignant neoplasm at the time of the clinical onset of rapidly progressive crescentic glomerulonephritis;
- (6)taking a drug or a drug from a class of drugs from the specified list of drugs within the seven days before the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of drugs is defined in the Schedule 1 - Dictionary.
- (7)having at least three episodes of acute volatile substance intoxication within the 30 days before the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: acute volatile substance intoxication is defined in the Schedule 1 - Dictionary.
- (8)inhaling or absorbing an organic solvent for at least one hour per week for at least the three months before the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: organic solvent is defined in the Schedule 1 - Dictionary.
- (9)inability to obtain appropriate clinical management for rapidly progressive crescentic glomerulonephritis;
Aggravation-only factors: the factors in subsection 9(9) apply only to material contribution to, or aggravation of, the condition where it was suffered or contracted before or during (but did not arise out of) the person’s relevant service.
Balance of Probabilities (BoP) — Statement of Principles No. 46 of 2019
7 factors
At least one of the following factors must exist before it can be said that, on the balance of probabilities, rapidly progressive crescentic glomerulonephritis or death from rapidly progressive crescentic glomerulonephritis is connected with the circumstances of a person's relevant service:
- (1)having an infection from the specified list of infections within the two months before the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of infections is defined in the Schedule 1 - Dictionary.
- (2)having an autoimmune disorder from the specified list of autoimmune disorders at the time of the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of autoimmune disorders is defined in the Schedule 1 - Dictionary.
- (3)having infiltration of the kidneys due to a disorder from the specified list of infiltrative disorders at the time of the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of infiltrative disorders is defined in the Schedule 1 - Dictionary.
- (4)having a renal disorder from the specified list of renal disorders at the time of the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of renal disorders is defined in the Schedule 1 - Dictionary.
- (5)having a malignant neoplasm at the time of the clinical onset of rapidly progressive crescentic glomerulonephritis;
- (6)taking a drug from the specified list of drugs within the seven days before the clinical onset of rapidly progressive crescentic glomerulonephritis;
Note: specified list of drugs is defined in the Schedule 1 - Dictionary.
- (7)inability to obtain appropriate clinical management for rapidly progressive crescentic glomerulonephritis;
Aggravation-only factors: the factors in subsection 9(7) apply only to material contribution to, or aggravation of, the condition where it was suffered or contracted before or during (but did not arise out of) the person’s relevant service.








